Last edited by Shakale
Wednesday, October 14, 2020 | History

1 edition of Pharmacokinetic-Pharmacodynamic Modeling and Simulation found in the catalog.

Pharmacokinetic-Pharmacodynamic Modeling and Simulation

Peter L. Bonate

Pharmacokinetic-Pharmacodynamic Modeling and Simulation

by Peter L. Bonate

  • 333 Want to read
  • 37 Currently reading

Published by Springer Science+Business Media, LLC in Boston, MA .
Written in English

    Subjects:
  • Medicine,
  • Toxicology

  • Edition Notes

    Statementby Peter L. Bonate
    ContributionsSpringerLink (Online service)
    The Physical Object
    Format[electronic resource] /
    ID Numbers
    Open LibraryOL25545559M
    ISBN 109781441994844, 9781441994851

    This book presents both the art and science behind pharmacokinetic-pharmacodynamic modeling. Using a building-block approach, the author starts from linear and nonlinear models at the individual level and proceeds to develop more complex linear and nonlinear mixed effects models at the population level, with particular emphasis on showing the interrelationships between the various model types.5/5(1). Pharmacokinetic / pharmacodynamic modeling and simulation in the design and analysis of Randomized Concentration-Controlled Trials (RCCTs) N. Seth Berry, PharmD Senior Scientific Advisor Quantitative Decision Strategies & Analytics.

    He has more than 50 publications in the field of pharmacokinetics and clinical pharmacology, is co-editor of the 3-volume series Pharmacokinetics in Drug Development published by AAPS Press in and , and is author of the book Pharmacokinetic-Pharmacodynamic Modeling and Simulation published by Springer in   Pharmacokinetic-Pharmacodynamic Modeling and Simulation by Peter L. Bonate This is a second edition to the original published by Springer in The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models.

    Peter Bonate is the author of Pharmacokinetic-Pharmacodynamic Modeling and Simulation ( avg rating, 6 ratings, 0 reviews, published ), Be a Model /5(8).   Understanding the dose–concentration–effect relationship is a fundamental component of clinical pharmacology. Interpreting data arising from observations of this relationship requires the use of mathematical models; i.e. pharmacokinetic (PK) models to describe the relationship between dose and concentration and pharmacodynamic (PD) models describing the relationship between concentration Cited by:


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Pharmacokinetic-Pharmacodynamic Modeling and Simulation by Peter L. Bonate Download PDF EPUB FB2

Since its publication inPharmacokinetic-Pharmacodynamic Modeling and Simulation has become the leading text on modeling of pharmacokinetic and pharmacodynamic data using nonlinear mixed effects models and has been applauded by students and teachers for its readability and exposition of complex statistical topics.

Using a building block approach, the text starts with linear regression Cited by: Since its publication inPharmacokinetic-Pharmacodynamic Modeling and Simulation has become the leading text on modeling of pharmacokinetic and pharmacodynamic data using nonlinear mixed effects models and has been applauded by students and teachers for its readability and exposition of complex statistical topics.

Using a building block approach, the text starts with linear regression. The purpose of Pharmacokinetic-Pharmacodynamic Modeling and Simulation is to provide pharmacokineticists and pharmacy graduate students with the statistical and modeling background necessary to perform population pharmacokinetics analyses.

As the author says, “Models that are reported in the literature are not picked out of thin by: 4. He has more than 50 publications in the field of pharmacokinetics and clinical pharmacology, is co-editor of the 3-volume series Pharmacokinetics in Drug Development published by AAPS Press in andand is author of the book Pharmacokinetic-Pharmacodynamic Modeling and Simulation published by Springer in Inhe became an.

This book provides a user-friendly, hands-on introduction to the Nonlinear Mixed Effects Modeling (NONMEM) system, the most powerful tool for pharmacokinetic / pharmacodynamic analysis.

• Introduces requisite background to using Nonlinear Mixed Effects Modeling (NONMEM), covering data requirements, model building and evaluation, and quality. Pharmacokinetic-Pharmacodynamic Modeling and Simulation book book presents both the art and science behind pharmacokinetic-pharmacodynamic modeling.

Using a building-block approach, the author starts from linear and nonlinear models at the individual level and proceeds to develop more complex linear and nonlinear mixed effects models at the population level, with particular emphasis on showing the interrelationships between the various model types.

Pharmacokinetic– pharmacodynamic modeling Roflumilast pharmacokinetics have been studied using a two-compartment model with first-order absorption and a lag time Modeling and Simulation, Model-based Drug Development and the Emerging Discipline of Pharmacometrics this book provides guidance for researchers performing mechanistic.

Whereas traditional pharmacokinetic-pharmacodynamic modeling takes an empirical or mechanistic approach to modeling, QSP takes a holistic approach exploring whole biochemical and metabolic.

Read "Pharmacokinetic-Pharmacodynamic Modeling and Simulation" by Peter L. Bonate available from Rakuten Kobo. This is a second edition to the original published by Springer in The comprehensive volume takes a textbook approa Brand: Springer US. Buy Pharmacokinetic-Pharmacodynamic Modeling and Simulation 2nd ed.

by Bonate, Peter L. (ISBN: ) from Amazon's Book Store. Everyday low prices and free delivery on eligible orders/5(2). Download Citation | Pharmacokinetic-Pharmacodynamic Modeling and Simulation | The Art of Modeling.- Linear Models and Regression.- Nonlinear Models and Regression.- Variance Models, Weighting, and.

"This book presents both the art and science behind pharmacokinetic-pharmacodynamic modeling. Using a building-block approach, the author starts from linear and nonlinear models at the individual level and proceeds to develop more complex linear and nonlinear mixed effects models at the population level, with particular emphasis on showing the interrelationships between the various model types.

Scopri Pharmacokinetic-Pharmacodynamic Modeling and Simulation di Peter L., Ph.D. Bonate: spedizione gratuita per i clienti Prime e per ordini a partire da 29€ spediti da Amazon/5(2).

Medical Book Pharmacokinetic-Pharmacodynamic Modeling and Simulation The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Print book: English: 2nd edView all editions and formats Summary: This leading text on modeling of pharmacokinetic and pharmacodynamic data using nonlinear mixed effects models uses a.

This is a second edition to the original published by Springer in The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models.

Since the first edition was Brand: Springer US. High drug attrition rates remain a critical issue in oncology drug development. A series of steps during drug development must be addressed to better understand the pharmacokinetic (PK) and pharmacodynamic (PD) properties of novel agents and, thus, increase their probability of success.

As available data continues to expand in both volume and complexity, comprehensive integration of PK Cited by: 7. Book Description. Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices.

Pharmacokinetic and pharmacodynamic modeling and simulation are well-recognized powerful tools that enable effective implementation of the learn-and-confirm paradigm in drug development.

56 These tools can be used to expedite the identification and testing of appropriate drug doses, particularly drugs that have a narrow range of safe and. Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation :.

Find many great new & used options and get the best deals for Pharmacokinetic-Pharmacodynamic Modeling and Simulation by Peter L. Bonate (, Paperback) at the best online prices at eBay! Free shipping for many products!Bonate, P.L. Pharmacokinetic-Pharmacodynamic Modeling and Simulation, 2nd ed, Springer, New York, NY ISBN Bonate, P.L.

Pharmacokinetic-Pharmacodynamic Modeling and Simulation, Springer, New York, NY ISBN X.Summary This chapter contains sections titled: Introduction Biomarkers in PK and PD Model‐Based Clinical Drug Development First‐in‐Human Dose Examples Discussion and Conclusion ReferencesAuthor: Lingling Guan.